New approaches to in vitro models of blood-brain barrier drug transport

Tetsuya Terasaki, Sumio Ohtsuki, Satoko Hori, Hitomi Takanaga, Emi Nakashima, Ken Ichi Hosoya

研究成果: Review article査読

141 被引用数 (Scopus)

抄録

The pharmaceutical industry has been searching for an in vitro blood-brain barrier (BBB) model that preserves in vivo transporter functions in CNS drug discovery and development. The application of conditionally immortalized cell lines derived from transgenic animals harboring temperature-sensitive SV40 large T-antigen gene, is a rational and promising approach to such a workable in vitro BBB model. The established brain capillary endothelial cell lines retain the in vivo transport rate of several compounds and various forms of gene expression. Furthermore, this new approach has enabled the development of stable and reproducible co-culture models with a pericyte cell line and/or an astrocyte cell line.

本文言語English
ページ(範囲)944-954
ページ数11
ジャーナルDrug Discovery Today
8
20
DOI
出版ステータスPublished - 2003 10 15

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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