New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome

Akitoshi Ishizaka, Masazumi Watanabe, Tetsuji Yamashita, Yasuyo Ogawa, Hidefumi Koh, Naoki Hasegawa, Hidetoshi Nakamura, Koichiro Asano, Kazuhiro Yamaguchi, Mariko Kotani, Toru Kotani, Hiroshi Morisaki, Junzo Takeda, Koichi Kobayashi, Satoshi Ogawa

研究成果: Article

85 引用 (Scopus)

抄録

Objective: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. Design: Observational, controlled study. Setting: Intensive care unit of academic medical center. Patients and Procedure: BMS was applied in a control group of seven patients who had hemoptysis or small solitary peripheral nodules but no hypoxemia or other signs of acute inflammation and in four patients with acute respiratory distress syndrome (ARDS), to test whether BMS can ascertain the presence of acute pulmonary inflammation without complications. Measurements and Results: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BUS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p < .0001, p = .012, p < .0001, p < .0001, and p < .0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. Conclusions: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.

元の言語English
ページ(範囲)896-898
ページ数3
ジャーナルCritical Care Medicine
29
発行部数4
出版物ステータスPublished - 2001

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Adult Respiratory Distress Syndrome
Inflammation
Leukocyte Elastase
Control Groups
Hemoptysis
Fibroblast Growth Factor 2
L-Lactate Dehydrogenase
Observational Studies
Intensive Care Units
Albumins
Interleukin-6
Pneumonia
Biomarkers
Oxygen
Lung

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

これを引用

New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome. / Ishizaka, Akitoshi; Watanabe, Masazumi; Yamashita, Tetsuji; Ogawa, Yasuyo; Koh, Hidefumi; Hasegawa, Naoki; Nakamura, Hidetoshi; Asano, Koichiro; Yamaguchi, Kazuhiro; Kotani, Mariko; Kotani, Toru; Morisaki, Hiroshi; Takeda, Junzo; Kobayashi, Koichi; Ogawa, Satoshi.

:: Critical Care Medicine, 巻 29, 番号 4, 2001, p. 896-898.

研究成果: Article

Ishizaka, A, Watanabe, M, Yamashita, T, Ogawa, Y, Koh, H, Hasegawa, N, Nakamura, H, Asano, K, Yamaguchi, K, Kotani, M, Kotani, T, Morisaki, H, Takeda, J, Kobayashi, K & Ogawa, S 2001, 'New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome', Critical Care Medicine, 巻. 29, 番号 4, pp. 896-898.
Ishizaka, Akitoshi ; Watanabe, Masazumi ; Yamashita, Tetsuji ; Ogawa, Yasuyo ; Koh, Hidefumi ; Hasegawa, Naoki ; Nakamura, Hidetoshi ; Asano, Koichiro ; Yamaguchi, Kazuhiro ; Kotani, Mariko ; Kotani, Toru ; Morisaki, Hiroshi ; Takeda, Junzo ; Kobayashi, Koichi ; Ogawa, Satoshi. / New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome. :: Critical Care Medicine. 2001 ; 巻 29, 番号 4. pp. 896-898.
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abstract = "Objective: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. Design: Observational, controlled study. Setting: Intensive care unit of academic medical center. Patients and Procedure: BMS was applied in a control group of seven patients who had hemoptysis or small solitary peripheral nodules but no hypoxemia or other signs of acute inflammation and in four patients with acute respiratory distress syndrome (ARDS), to test whether BMS can ascertain the presence of acute pulmonary inflammation without complications. Measurements and Results: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BUS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p < .0001, p = .012, p < .0001, p < .0001, and p < .0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. Conclusions: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.",
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T1 - New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome

AU - Ishizaka, Akitoshi

AU - Watanabe, Masazumi

AU - Yamashita, Tetsuji

AU - Ogawa, Yasuyo

AU - Koh, Hidefumi

AU - Hasegawa, Naoki

AU - Nakamura, Hidetoshi

AU - Asano, Koichiro

AU - Yamaguchi, Kazuhiro

AU - Kotani, Mariko

AU - Kotani, Toru

AU - Morisaki, Hiroshi

AU - Takeda, Junzo

AU - Kobayashi, Koichi

AU - Ogawa, Satoshi

PY - 2001

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N2 - Objective: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. Design: Observational, controlled study. Setting: Intensive care unit of academic medical center. Patients and Procedure: BMS was applied in a control group of seven patients who had hemoptysis or small solitary peripheral nodules but no hypoxemia or other signs of acute inflammation and in four patients with acute respiratory distress syndrome (ARDS), to test whether BMS can ascertain the presence of acute pulmonary inflammation without complications. Measurements and Results: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BUS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p < .0001, p = .012, p < .0001, p < .0001, and p < .0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. Conclusions: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.

AB - Objective: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. Design: Observational, controlled study. Setting: Intensive care unit of academic medical center. Patients and Procedure: BMS was applied in a control group of seven patients who had hemoptysis or small solitary peripheral nodules but no hypoxemia or other signs of acute inflammation and in four patients with acute respiratory distress syndrome (ARDS), to test whether BMS can ascertain the presence of acute pulmonary inflammation without complications. Measurements and Results: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BUS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p < .0001, p = .012, p < .0001, p < .0001, and p < .0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. Conclusions: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.

KW - Acute inflammatory lung injury

KW - Acute respiratory distress syndrome

KW - Bronchoalveolar lavage

KW - Bronchoscopic microsampling

KW - Epithelial lining fluid

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