New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: Taxonomy, fermentation, isolation, structural elucidation and biological properties

Toshio Otani, Yoshikazu Sugimoto, Yoshimi Aoyagi, Yasuhiro Igarashi, Tamotsu Furumai, Noriko Saito, Yuji Yamada, Tetsuji Asao, Toshikazu Oki

研究成果: Article

38 引用 (Scopus)

抄録

Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also possessing antifungal activity, designated nocardiones A (1) and B (2), was considered to belong to the genus Nocardia on the basis of literature comparison of chemotaxonomic properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography. Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones. Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 μM. It also showed moderate in vitro antifungal and cytotoxic activity.

元の言語English
ページ(範囲)337-344
ページ数8
ジャーナルJournal of Antibiotics
53
発行部数4
出版物ステータスPublished - 2000 4
外部発表Yes

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cdc25 Phosphatases
Nocardia
Fermentation
Tyrosine
Protein Tyrosine Phosphatases
Chromatography
nocardione A
nocardione B

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

これを引用

New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248 : Taxonomy, fermentation, isolation, structural elucidation and biological properties. / Otani, Toshio; Sugimoto, Yoshikazu; Aoyagi, Yoshimi; Igarashi, Yasuhiro; Furumai, Tamotsu; Saito, Noriko; Yamada, Yuji; Asao, Tetsuji; Oki, Toshikazu.

:: Journal of Antibiotics, 巻 53, 番号 4, 04.2000, p. 337-344.

研究成果: Article

Otani, Toshio ; Sugimoto, Yoshikazu ; Aoyagi, Yoshimi ; Igarashi, Yasuhiro ; Furumai, Tamotsu ; Saito, Noriko ; Yamada, Yuji ; Asao, Tetsuji ; Oki, Toshikazu. / New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248 : Taxonomy, fermentation, isolation, structural elucidation and biological properties. :: Journal of Antibiotics. 2000 ; 巻 53, 番号 4. pp. 337-344.
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AU - Otani, Toshio

AU - Sugimoto, Yoshikazu

AU - Aoyagi, Yoshimi

AU - Igarashi, Yasuhiro

AU - Furumai, Tamotsu

AU - Saito, Noriko

AU - Yamada, Yuji

AU - Asao, Tetsuji

AU - Oki, Toshikazu

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