New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: Taxonomy, fermentation, isolation, structural elucidation and biological properties

Toshio Otani, Yoshikazu Sugimoto, Yoshimi Aoyagi, Yasuhiro Igarashi, Tamotsu Furumai, Noriko Saito, Yuji Yamada, Tetsuji Asao, Toshikazu Oki

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also possessing antifungal activity, designated nocardiones A (1) and B (2), was considered to belong to the genus Nocardia on the basis of literature comparison of chemotaxonomic properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography. Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones. Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 μM. It also showed moderate in vitro antifungal and cytotoxic activity.

本文言語English
ページ(範囲)337-344
ページ数8
ジャーナルJournal of Antibiotics
53
4
DOI
出版ステータスPublished - 2000 4月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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