抄録
Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also possessing antifungal activity, designated nocardiones A (1) and B (2), was considered to belong to the genus Nocardia on the basis of literature comparison of chemotaxonomic properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography. Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones. Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 μM. It also showed moderate in vitro antifungal and cytotoxic activity.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 337-344 |
| ページ数 | 8 |
| ジャーナル | Journal of Antibiotics |
| 巻 | 53 |
| 発行部数 | 4 |
| 出版物ステータス | Published - 2000 4 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
これを引用
New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248 : Taxonomy, fermentation, isolation, structural elucidation and biological properties. / Otani, Toshio; Sugimoto, Yoshikazu; Aoyagi, Yoshimi; Igarashi, Yasuhiro; Furumai, Tamotsu; Saito, Noriko; Yamada, Yuji; Asao, Tetsuji; Oki, Toshikazu.
：: Journal of Antibiotics, 巻 53, 番号 4, 04.2000, p. 337-344.研究成果: Article
}
TY - JOUR
T1 - New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248
T2 - Taxonomy, fermentation, isolation, structural elucidation and biological properties
AU - Otani, Toshio
AU - Sugimoto, Yoshikazu
AU - Aoyagi, Yoshimi
AU - Igarashi, Yasuhiro
AU - Furumai, Tamotsu
AU - Saito, Noriko
AU - Yamada, Yuji
AU - Asao, Tetsuji
AU - Oki, Toshikazu
PY - 2000/4
Y1 - 2000/4
N2 - Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also possessing antifungal activity, designated nocardiones A (1) and B (2), was considered to belong to the genus Nocardia on the basis of literature comparison of chemotaxonomic properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography. Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones. Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 μM. It also showed moderate in vitro antifungal and cytotoxic activity.
AB - Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also possessing antifungal activity, designated nocardiones A (1) and B (2), was considered to belong to the genus Nocardia on the basis of literature comparison of chemotaxonomic properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography. Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones. Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 μM. It also showed moderate in vitro antifungal and cytotoxic activity.
UR - http://www.scopus.com/inward/record.url?scp=0034065967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034065967&partnerID=8YFLogxK
M3 - Article
C2 - 10866214
AN - SCOPUS:0034065967
VL - 53
SP - 337
EP - 344
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 4
ER -