New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Yuji Narukawa, Akiko Niimura, Hitomi Noguchi, Hiroomi Tamura, Fumiyuki Kiuchi

研究成果: Article

18 引用 (Scopus)

抜粋

Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC 50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).

元の言語English
ページ(範囲)125-131
ページ数7
ジャーナルJournal of Natural Medicines
68
発行部数1
DOI
出版物ステータスPublished - 2014 1 1

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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