New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Yuuji Narukawa, Akiko Niimura, Hitomi Noguchi, Hiroomi Tamura, Fumiyuki Kiuchi

研究成果: Article

17 引用 (Scopus)

抄録

Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC 50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).

元の言語English
ページ(範囲)125-131
ページ数7
ジャーナルJournal of Natural Medicines
68
発行部数1
DOI
出版物ステータスPublished - 2014 1

Fingerprint

Leonurus
Diterpenes
Meclofenamic Acid
Acetone
Human Activities
Liver
Cytosol
Inhibitory Concentration 50
Estrogens
Maintenance
Antennas
estrone sulfotransferase

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Medicine(all)

これを引用

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abstract = "Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC 50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).",
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AU - Noguchi, Hitomi

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AU - Kiuchi, Fumiyuki

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AB - Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC 50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).

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