New flavanol dimers from the bark of celtis tetrandra and their TRAIL Resistance-Overcoming activity

Prapairat Seephonkai, Ryusho Ishikawa, Midori A. Arai, Thaworn Kowithayakorn, Takashi Koyano, Masami Ishibashi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

In the courses of our search for bioactive natural products on TRAIL resistance-overcoming activity, the active EtOAc extract from the bark of Celtis tetrandra was chemically investigated. The fractionation of the extract resulted in the isolation of flavanols; (+)-afzelechin (1), (-)-epiafzelechin (2), (-)-catechin (3), and two new flavanol dimers; (-)-epiafzelechin-(4α8)-(-)-catechin (4) and (-)-epiafzelechin-(4α 8)-(-)-epicatechin (5). All isolated compounds 1-5 were tested for their TRAIL resistance-overcoming activity against AGS cells at the concentrations from 5-20 µM. It is likely that the flavanol dimers 4 and 5 exhibited weak activity in the range of the concentration of 10-20 µM as compared with the standard.

本文言語English
ページ(範囲)427-430
ページ数4
ジャーナルNatural product communications
13
4
DOI
出版ステータスPublished - 2018 4
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 植物科学
  • 創薬
  • 補完代替医療

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