New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou

Hiroyuki Fuchino, Fumiyuki Kiuchi, Azusa Yamanaka, Akihiro Obu, Hiroshi Wada, Kanami Mori-Yasumoto, Nobuo Kawahara, Diana Flores, Olga Palacios, Setsuko Sekita, Motoyoshi Satake

研究成果: Article

4 引用 (Scopus)

抜粋

Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC50: 5.5, 3.9μg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC50: 9.9, 12.8, 22.6, 19.6μg/mL, respectively).

元の言語English
ページ(範囲)979-982
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
61
発行部数9
DOI
出版物ステータスPublished - 2013 9

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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    Fuchino, H., Kiuchi, F., Yamanaka, A., Obu, A., Wada, H., Mori-Yasumoto, K., Kawahara, N., Flores, D., Palacios, O., Sekita, S., & Satake, M. (2013). New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou. Chemical and Pharmaceutical Bulletin, 61(9), 979-982. https://doi.org/10.1248/cpb.c13-00385