New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno

研究成果: Article

49 引用 (Scopus)

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A new model-independent method is proposed for evaluating the in vitro dissolution time and disintegration time of solid dosage forms. The mean in vitro dissolution time (in vitro MDT) is defined as the first moment of the dissolution rate-time curve, that is, [formula omited], where dm/dt is the dissolution rate of a drug at time t. The mean in vitro disintegration time (in vitro MDIT) is defined by subtraction of MDT for drug powder from that for its tablet or capsule. The MDT is correlated with the parameters of several dissolution models.

元の言語English
ページ(範囲)1088-1090
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
30
発行部数3
DOI
出版物ステータスPublished - 1982
外部発表Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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