New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno

研究成果: Article査読

53 被引用数 (Scopus)

抄録

A new model-independent method is proposed for evaluating the in vitro dissolution time and disintegration time of solid dosage forms. The mean in vitro dissolution time (in vitro MDT) is defined as the first moment of the dissolution rate-time curve, that is, [formula omited], where dm/dt is the dissolution rate of a drug at time t. The mean in vitro disintegration time (in vitro MDIT) is defined by subtraction of MDT for drug powder from that for its tablet or capsule. The MDT is correlated with the parameters of several dissolution models.

本文言語English
ページ(範囲)1088-1090
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
30
3
DOI
出版ステータスPublished - 1982
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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