New neurons clear the path of astrocytic processes for their rapid migration in the adult brain

Naoko Kaneko, Oscar Marín, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y. Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R. Rubenstein, Kazunobu Sawamoto

研究成果: Article査読

167 被引用数 (Scopus)

抄録

In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young neurons achieve this by migrating in chains through astrocytic tunnels. Here, we report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational changes in astrocytes that result in the formation and maintenance of the astrocytic tunnels. Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain.

本文言語English
ページ(範囲)213-223
ページ数11
ジャーナルNeuron
67
2
DOI
出版ステータスPublished - 2010 7

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「New neurons clear the path of astrocytic processes for their rapid migration in the adult brain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル