New neurons follow the flow of cerebrospinal fluid in the adult brain

Kazunobu Sawamoto, Hynek Wichterle, Oscar Gonzalez-Perez, Jeremy A. Cholfin, Masayuki Yamada, Nathalie Spassky, Noel S. Murcia, Jose Manuel Garcia-Verdugo, Oscar Marin, John L.R. Rubenstein, Marc Tessier-Lavigne, Hideyuki Okano, Arturo Alvarez-Buylla

研究成果: Article査読

554 被引用数 (Scopus)

抄録

In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.

本文言語English
ページ(範囲)629-632
ページ数4
ジャーナルScience
311
5761
DOI
出版ステータスPublished - 2006 2 3

ASJC Scopus subject areas

  • General

フィンガープリント 「New neurons follow the flow of cerebrospinal fluid in the adult brain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル