New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

本文言語English
ページ(範囲)1495-1496
ページ数2
ジャーナルChemical and Pharmaceutical Bulletin
52
12
DOI
出版ステータスPublished - 2004 12月
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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