New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida, Yuka Furuno, Seiichiro Ogawa

研究成果: Article査読

27 被引用数 (Scopus)

抄録

A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.

本文言語English
ページ(範囲)1230-1231
ページ数2
ジャーナルJournal of the Chemical Society, Chemical Communications
17
DOI
出版ステータスPublished - 1989 1 1

ASJC Scopus subject areas

  • 分子医療

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