New targeted approach to CRPC

研究成果: Chapter

抄録

Our understanding of the heterogeneity and genetic characteristics of CRPC demonstrates underlying their complexity, which has been thought to be associated with their intractability. Recent advance of integrative next generation sequencing unveiled the extensive mutational landscape of metastatic CRPC, many of which can be a targetable mutation and been linked to ongoing clinical trials. Molecular stratification of patient groups will clearly be critical to successful drug development and clinical trials from the view point of precision medicine. In this review, we discuss the potential of new targeted approach to impact the clinical management of CRPC.

本文言語English
ホスト出版物のタイトルHormone Therapy and Castration Resistance of Prostate Cancer
出版社Springer Singapore
ページ375-385
ページ数11
ISBN(電子版)9789811070136
ISBN(印刷版)9789811070129
DOI
出版ステータスPublished - 2018 5 11

ASJC Scopus subject areas

  • Medicine(all)

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