Next-generation immunotherapies for brain metastatic cancers

María López Vázquez, Wanlu Du, Nobuhiko Kanaya, Yohei Kitamura, Khalid Shah

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Patients with extracranial tumors, like lung, breast, and skin cancers, often develop brain metastases (BM) during the course of their diseases and BM commonly represent the terminal stage of cancer progression. Recent insights in the immune biology of BM and the increasing focus of immunotherapy as a therapeutic option for cancer has prompted testing of promising biological immunotherapies, including immune cell-targeting, virotherapy, vaccines, and different cell-based therapies. Here, we review the pathobiology of BM progression and evaluate the potential of next-generation immunotherapies for BM tumors. We also provide future perspectives on the development and implementation of such therapies for brain metastatic cancer patients.

本文言語English
ページ(範囲)809-822
ページ数14
ジャーナルTrends in Cancer
7
9
DOI
出版ステータスPublished - 2021 9月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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