NF-B, inflammation, immunity and cancer: Coming of age

Koji Taniguchi, Michael Karin

研究成果: Review article査読

847 被引用数 (Scopus)

抄録

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.

本文言語English
ページ(範囲)309-324
ページ数16
ジャーナルNature Reviews Immunology
18
5
DOI
出版ステータスPublished - 2018 5 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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