Nickel(II)-promoted amide N-H arylation of pyroglutamate-histidine with arylboronic acid reagents

Kengo Hanaya, Mary K. Miller, Zachary T. Ball

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Small and simple bioorthogonal reactive handles that can be readily encoded by natural processes are important for bioconjugation. A rapid nickel-promoted N-H arylation of pyroglutamate-histidine sequences with 2-nitroarylboronic acids proceeds under mild aqueous conditions. Chemoselective activation of a lactam amide N-H within a peptide or protein provides a new approach to selective conjugation in polyamide structures.

本文言語English
ページ(範囲)2445-2448
ページ数4
ジャーナルOrganic Letters
21
7
DOI
出版ステータスPublished - 2019 4 5
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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