Nine Japanese patients with immotile-dyskinetic cilia syndrome: An ultrastructural study using tannic acid-containing fixation

Chikao Torikata, Takeshi Kawai, Shigeru Nogawa, Kazushige Ikeda, Koichi Shimizu, Chuichi Kijimoto

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Respiratory cilia and sperm flagella of nine Japanese patients with immotile-dyskinetic cilia syndrome were studied ultrastructurally by using a tannic acid-containing fixative. Respiratory cilia from two female patients with Kartagener's syndrome and one male patient with situs inversus and sinobronchitis were completely immotile and lacked both dynein arms. However, approximately 30% of the spermatozoa from the male patient were weakly motile. In four patients with immotile cilia syndrome without Kartagener's triad, immotile respiratory cilia generally lacked the inner dynein arms. Two clinically unusual cases, an 11-year-old boy and a 29-year-old woman with prolonged saccharin test, recurrent bronchitis, and bronchiectasia, possessed motile respiratory cilia. Ultrastructurally, both dynein arms were normal, but numerous defective central pairs (more than 50% and 70%, respectively) were seen, and the defect in the second case was similar to the transposition of microtubules reported by Sturgess et al (N Engl J Med 303:318-322, 1980). However, defects in the first case were unique and may be congenital. We propose a new type of dyskinetic cilia syndrome with defective central pairs. Additionally, nasal cilia from a 35-year-old man with immotile cilia syndrome contained excess large singlets within ciliary axonemes consisting of 17 protofilaments.

本文言語English
ページ(範囲)830-836
ページ数7
ジャーナルHuman Pathology
22
8
DOI
出版ステータスPublished - 1991 8月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学

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