Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo

Suraj Prakash Shrestha, Yuri Amano, Yuji Narukawa, Tadahiro Takeda

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC50 of 31.6 μM.

本文言語English
ページ(範囲)98-101
ページ数4
ジャーナルJournal of Natural Products
71
1
DOI
出版ステータスPublished - 2008 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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