TY - JOUR
T1 - Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo
AU - Shrestha, Suraj Prakash
AU - Amano, Yuri
AU - Narukawa, Yuji
AU - Takeda, Tadahiro
PY - 2008/1
Y1 - 2008/1
N2 - Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC50 of 31.6 μM.
AB - Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC50 of 31.6 μM.
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U2 - 10.1021/np070478h
DO - 10.1021/np070478h
M3 - Article
C2 - 18154272
AN - SCOPUS:39049166525
VL - 71
SP - 98
EP - 101
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 1
ER -