NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids

Maho Yagi-Utsumi, Takumi Yamaguchi, Yoshinori Uekusa, Koichi Kato

研究成果: Chapter

4 引用 (Scopus)

抜粋

Glycosphingolipids, including gangliosides, can form clusters on membranes and thereby mediate a variety of physiological and pathological functions. This chapter illustrates recent nuclear magnetic resonance (NMR) approaches for elucidating the molecular mechanisms underlying the functional roles of glycosphingolipid clusters, particularly focusing on the conformational dynamics and interactions of gangliosides. Dynamic conformational ensembles of ganglioside glycans in solution have been elucidated using molecular dynamics simulations validated by NMR data. Intermolecular interactions of glycosphingolipids in membrane-like environments have been characterized using solution and solid-state NMR techniques. Various membrane mimics have been developed for NMR studies on the interactions between ganglioside clusters and amyloidogenic proteins associated with neurodegenerative disorders.

元の言語English
ホスト出版物のタイトルBiophysics and Biochemistry of Cartilage by NMR and MRI
編集者William S. Price, Koichi Kato, Thomas Peters
出版者Royal Society of Chemistry
ページ161-178
ページ数18
エディション10
ISBN(電子版)9781782621331, 9781782623106, 9781849736190
DOI
出版物ステータスPublished - 2017 1 1
外部発表Yes

出版物シリーズ

名前New Developments in NMR
番号10
2017-January
ISSN(印刷物)2044-253X
ISSN(電子版)2044-2548

ASJC Scopus subject areas

  • Analytical Chemistry
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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  • これを引用

    Yagi-Utsumi, M., Yamaguchi, T., Uekusa, Y., & Kato, K. (2017). NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids. : W. S. Price, K. Kato, & T. Peters (版), Biophysics and Biochemistry of Cartilage by NMR and MRI (10 版, pp. 161-178). (New Developments in NMR; 巻数 2017-January, 番号 10). Royal Society of Chemistry. https://doi.org/10.1039/9781782623946-00161