Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41

Shun Saito, Shiina Suzuki, Midori A. Arai

研究成果: Article査読

抄録

The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a “heat shock metabolite” (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration.

本文言語English
ページ(範囲)509-513
ページ数5
ジャーナルJournal of Antibiotics
75
9
DOI
出版ステータスPublished - 2022 9月

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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