Noise-reduction filtering for accurate detection of replication termini in bacterial genomes

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Bacterial chromosomes are highly polarized in their nucleotide composition through mutational selection related to replication. Using compositional skews such as the GC skew, replication origin and terminus can be predicted in silico by observing the shift points. However, the genome sequence is affected by myriad functional requirements and selection on numerous subgenomic features, and elimination of this "noise" should lead to better predictions. Here, we present a noise-reduction approach that uses low-pass filtering through Fast Fourier transform coupled with cumulative skew graphs. It increases the prediction accuracy of the replication termini compared with previously documented methods based on genomic base composition.

本文言語English
ページ(範囲)253-258
ページ数6
ジャーナルFEBS Letters
581
2
DOI
出版ステータスPublished - 2007 1 23

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Noise-reduction filtering for accurate detection of replication termini in bacterial genomes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル