TY - JOUR
T1 - Non-alcoholic fatty liver disease in patients with autoimmune hepatitis
AU - Japan AIH Study Group (JAIHSG)
AU - Takahashi, Atsushi
AU - Arinaga-Hino, Teruko
AU - Ohira, Hiromasa
AU - Abe, Kazumichi
AU - Torimura, Takuji
AU - Zeniya, Mikio
AU - Abe, Masanori
AU - Yoshizawa, Kaname
AU - Takaki, Akinobu
AU - Suzuki, Yoshiyuki
AU - Kang, Jong Hon
AU - Nakamoto, Nobuhiro
AU - Fujisawa, Tomoo
AU - Tanaka, Atsushi
AU - Takikawa, Hajime
N1 - Publisher Copyright:
© 2018 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background and Aim: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with liver disease, including patients with autoimmune hepatitis (AIH). NAFLD and AIH have some similar laboratory and histological findings. The aim of this study was to elucidate the characteristics of AIH patients with NAFLD. Methods: We re-evaluated the nationwide survey performed in Japan in 2015 of AIH patients diagnosed between 2009 and 2013. Results: A total of 1151 subjects (144 men and 1007 women) were enrolled in the present study. The overall prevalence of NAFLD was 17.0%. Compared to AIH without NAFLD, AIH patients with NAFLD had the following characteristics: (i) low female-to-male ratio, (ii) older age, (iii) mild elevation in hepatobiliary enzymes, (iv) histologically progressive fibrosis and mild plasma cell infiltration or mild lobular hepatitis, (v) lower prevalence of prednisolone administration and higher prevalence of ursodeoxycholic acid administration, (vi) higher levels of hepatic enzymes and immunoglobulin G after treatment, and (vii) similar prevalence of autoimmune and malignant complications. Conclusion: AIH patients with NAFLD have many features that are different from AIH patients without NAFLD. Understanding these differences is essential for the proper diagnosis and treatment of AIH patients with NAFLD.
AB - Background and Aim: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with liver disease, including patients with autoimmune hepatitis (AIH). NAFLD and AIH have some similar laboratory and histological findings. The aim of this study was to elucidate the characteristics of AIH patients with NAFLD. Methods: We re-evaluated the nationwide survey performed in Japan in 2015 of AIH patients diagnosed between 2009 and 2013. Results: A total of 1151 subjects (144 men and 1007 women) were enrolled in the present study. The overall prevalence of NAFLD was 17.0%. Compared to AIH without NAFLD, AIH patients with NAFLD had the following characteristics: (i) low female-to-male ratio, (ii) older age, (iii) mild elevation in hepatobiliary enzymes, (iv) histologically progressive fibrosis and mild plasma cell infiltration or mild lobular hepatitis, (v) lower prevalence of prednisolone administration and higher prevalence of ursodeoxycholic acid administration, (vi) higher levels of hepatic enzymes and immunoglobulin G after treatment, and (vii) similar prevalence of autoimmune and malignant complications. Conclusion: AIH patients with NAFLD have many features that are different from AIH patients without NAFLD. Understanding these differences is essential for the proper diagnosis and treatment of AIH patients with NAFLD.
KW - autoimmune hepatitis
KW - laboratory findings
KW - liver histological findings
KW - nationwide survey
KW - non-alcoholic fatty liver disease
KW - treatment
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U2 - 10.1002/jgh3.12046
DO - 10.1002/jgh3.12046
M3 - Article
AN - SCOPUS:85068015187
SN - 2397-9070
VL - 2
SP - 54
EP - 58
JO - JGH Open
JF - JGH Open
IS - 2
ER -