Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai; Jun Kohyama

doi:10.1016/j.stemcr.2019.01.011

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai, Jun Kohyama

生理学

研究成果: Short survey › 査読

6 被引用数 (Scopus)

抄録

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

本文言語	English
ページ（範囲）	183-185
ページ数	3
ジャーナル	Stem cell reports
巻	12
号	2
DOI	https://doi.org/10.1016/j.stemcr.2019.01.011
出版ステータス	Published - 2019 2 12

ASJC Scopus subject areas

生化学
遺伝学
発生生物学
細胞生物学

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10.1016/j.stemcr.2019.01.011

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title = "Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein",

abstract = "Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).",

author = "Chai, {Muh Chyi} and Jun Kohyama",

note = "Funding Information: J.K. is supported by the Japan Agency for Medical Research and Development (AMED) under grant number 18bm0404022h0001 . Publisher Copyright: {\textcopyright} 2019 The Authors",

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Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

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