Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai; Jun Kohyama

doi:10.1016/j.stemcr.2019.01.011

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai, Jun Kohyama

生理学

研究成果: Short survey › 査読

10 被引用数 (Scopus)

抄録

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

本文言語	English
ページ（範囲）	183-185
ページ数	3
ジャーナル	Stem cell reports
巻	12
号	2
DOI	https://doi.org/10.1016/j.stemcr.2019.01.011
出版ステータス	Published - 2019 2月 12

ASJC Scopus subject areas

生化学
遺伝学
発生生物学
細胞生物学

文献へのアクセス

10.1016/j.stemcr.2019.01.011

他のファイルとリンク

引用スタイル

@article{7c8bd4edc150451cafc1b2d97b923c9d,

title = "Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein",

abstract = "Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).",

author = "Chai, {Muh Chyi} and Jun Kohyama",

note = "Funding Information: J.K. is supported by the Japan Agency for Medical Research and Development (AMED) under grant number 18bm0404022h0001 . Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = feb,

day = "12",

doi = "10.1016/j.stemcr.2019.01.011",

language = "English",

volume = "12",

pages = "183--185",

journal = "Stem Cell Reports",

issn = "2213-6711",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

AU - Chai, Muh Chyi

AU - Kohyama, Jun

PY - 2019/2/12

Y1 - 2019/2/12

N2 - Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

AB - Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

UR - http://www.scopus.com/inward/record.url?scp=85060333027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060333027&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2019.01.011

DO - 10.1016/j.stemcr.2019.01.011

M3 - Short survey

C2 - 30759377

AN - SCOPUS:85060333027

VL - 12

SP - 183

EP - 185

JO - Stem Cell Reports

JF - Stem Cell Reports

SN - 2213-6711

IS - 2

ER -

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル