Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy

Yoshiko Ofuji, Yusaku Katada, Yohei Tomita, Norihiro Nagai, Hideki Sonobe, Kazuhiro Watanabe, Hajime Shinoda, Yoko Ozawa, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

研究成果: Article査読

抄録

Fundus fluorescent angiography is a standard examination in Japan that can directly visualize the circulatory failure in diabetic retinopathy but is not used in Western countries. In this study, we examine the relationship between the non-perfusion area in fundus fluorescent angiography and the progression of diabetic retinopathy. We evaluated 22 eyes between 22 patients who had their first fundus fluorescent angiography during a clinical episode at Keio University Hospital from January 2012 to May 2015, were diagnosed as having preproliferative diabetic retinopathy, and could be followed for at least three years. The non-perfusion area index (%) in nine segmented fundi in the initial fundus fluorescent angiography was calculated, and the progression to proliferative diabetic retinopathy over three years was evaluated. Three out of the 22 eyes (13.6%) developed proliferative diabetic retinopathy over three years. The non-perfusion area index for the initial fundus fluorescent angiography was significantly associated with progression to proliferative diabetic retinopathy. The non-perfusion area index in the posterior pole was most strongly correlated with the progression to proliferative diabetic retinopathy. Thus, the non-perfusion area index in the posterior pole among those with preproliferative diabetic retinopathy may predict the progression to proliferative diabetic retinopathy in the subsequent three years.

本文言語English
論文番号542
ジャーナルLife
12
4
DOI
出版ステータスPublished - 2022 4月

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 生化学、遺伝学、分子生物学(全般)
  • 宇宙惑星科学
  • 古生物学

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