TY - JOUR
T1 - Non-stereoselective Formation of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid during Cholic Acid Biosynthesis
AU - Kobayashi, Noriko
AU - Hagiwara, Chiaki
AU - Morisaki, Masuo
AU - Yuri, Masatoshi
AU - Oya, Izumi
AU - Fujimoto, Yoshinori
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Incubation of (25iRS)-, (25R)- and (25S)-3α, 7α, 12v-trihydroxy-5β-cholestan-26-oic acid (THCA, 6, 6a, 6b) and (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10, 11) were also converted non-stereoselectively to a 1:1 mixture of the epimeric 24-hydroxy compounds (12).
AB - Incubation of (25iRS)-, (25R)- and (25S)-3α, 7α, 12v-trihydroxy-5β-cholestan-26-oic acid (THCA, 6, 6a, 6b) and (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10, 11) were also converted non-stereoselectively to a 1:1 mixture of the epimeric 24-hydroxy compounds (12).
KW - 12α
KW - 12α
KW - 12α
KW - 24-tetrahydroxy- 5β
KW - 24-trihydroxy-5β
KW - 7α
KW - 7α
KW - 7α
KW - bile acid cholic acid β
KW - cholest-24-en-26-oic acid
KW - cholestan-26-oic acid 3α
KW - cholestan-26-oic acid 3α
KW - oxidation 3α
KW - trihydroxy-5β
UR - http://www.scopus.com/inward/record.url?scp=0028303773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028303773&partnerID=8YFLogxK
U2 - 10.1248/cpb.42.1028
DO - 10.1248/cpb.42.1028
M3 - Article
C2 - 8069953
AN - SCOPUS:0028303773
VL - 42
SP - 1028
EP - 1035
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 5
ER -