Non-stereoselective Formation of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid during Cholic Acid Biosynthesis

Noriko Kobayashi, Chiaki Hagiwara, Masuo Morisaki, Masatoshi Yuri, Izumi Oya, Yoshinori Fujimoto

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Incubation of (25iRS)-, (25R)- and (25S)-3α, 7α, 12v-trihydroxy-5β-cholestan-26-oic acid (THCA, 6, 6a, 6b) and (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10, 11) were also converted non-stereoselectively to a 1:1 mixture of the epimeric 24-hydroxy compounds (12).

本文言語English
ページ(範囲)1028-1035
ページ数8
ジャーナルChemical and Pharmaceutical Bulletin
42
5
DOI
出版ステータスPublished - 1994 1月 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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