Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo

Arisa Ito, Takuro Kajihara, Tsukasa Suenari, Mei Takahashi, Takehiro Kimura, Kotaro Fukumoto, Seiji Takatsuki, Shunichiro Miyoshi, Tsunenori Arai

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

We have studied a new type of myocardial catheter ablation with photosensitization reaction to realize non-thermal therapy for atrial arrhythmia, such as atrial fibrillation. Photochemically-generated reactive oxygen species may induce myocardial electrophysiological damage without heat generation. In this study, to demonstrate photosensitization reaction-induced myocardial electrical conduction block, the inferior vena cava to tricuspid annulus (IVC-TA) isthmus linear ablation was conducted with photosensitization reaction in porcine heart in vivo, using a newly developed laser catheter (7 Fr.). The end point of the procedure was the production of IVC-TA isthmus block under the electrophysiological analysis by diagnostic catheter with 10-bipole electrodes placed in right atrium along the isthmus. Talaporfin sodium (NPe6) as a photosensitizer was injected intravenously to pigs at 2.5-5.0 mg/kg. About 15 min after the injection, the laser light at the wavelength of 663 nm with a catheter output power density of 40-60 W/cm2 in about 1.4 mm spot size was irradiated through the laser catheter point by point in line crossing the isthmus under the fluoroscopic guidance. Before the photosensitization procedure, pacing signal from the distal electrodes of the diagnostic catheter, propagated through the isthmus in order. During the irradiation, electrical potential at the irradiated area was diminished. After the completion of the irradiation line, the bidirectional conduction block on the IVC-TA isthmus was validated by pacing from the distal and proximal bipole. These results indicated that photosensitization reaction could achieve the electrical conduction block of myocardial tissue immediately after the irradiation. We think that photosensitization reaction could become a novel therapy for atrial arrhythmia.

本文言語English
ホスト出版物のタイトルPhotonic Therapeutics and Diagnostics VII
DOI
出版ステータスPublished - 2011 4 12
イベントPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
継続期間: 2011 1 222011 1 24

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
7883
ISSN(印刷版)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics VII
国/地域United States
CitySan Francisco, CA
Period11/1/2211/1/24

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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