Nonactin and related compounds found in a screening program for wnt signal inhibitory activity

Yuuya Tamai, Kazufumi Toume, Midori A. Arai, Akinori Hayashida, Hikaru Kato, Yoshikazu Shizuri, Sachiko Tsukamoto, Masami Ishibashi

研究成果: Article査読

9 被引用数 (Scopus)

抄録

A screening study using a luciferase assay to identify natural products with inhibitory activity against Wnt signaling was carried out. Fractionation of the culture extract of an actinomycete, strain CKK179, led to the identification of nonactin (1), monactin (2), and dinactin (3) as active compounds. We examined the effects of dimeric dinactin (4), isolated from another actinomycete, Streptomyces sp. (YM09-028), on Wnt signaling activity and found that 1 - 4 inhibited TCF/β-catenin transcriptional activity with IC50 values of 0.6 - 7.4 nM.

本文言語English
ページ(範囲)1245-1250
ページ数6
ジャーナルHeterocycles
84
2
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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