Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest: A prospective multicenter observational study

Noritoshi Ito, Kei Nishiyama, Clifton W. Callaway, Tomohiko Orita, Kei Hayashida, Hideki Arimoto, Mitsuru Abe, Tomoyuki Endo, Akira Murai, Ken Ishikura, Noriaki Yamada, Masahiro Mizobuchi, Hideki Anan, Kazuo Okuchi, Hideto Yasuda, Toshiaki Mochizuki, Yuka Tsujimura, Takeo Nakayama, Tetsuo Hatanaka, Ken NagaoT. Suzuki, N. Sato, T. Kimura, K. Koike, T. Morooka, H. Rinka, T. Ikehara, M. Suzuki, A. Shirishita-Takeshita, S. Hori, T. Unoki, S. Beppu, I. Kaneko, Y. Toyoda, M. Kitano, M. Machida, H. Ishikura, T. Oomura, D. Kudo, S. Kushimoto, T. Watanabe, M. Fujioka, T. Seki, M. Otsuka, H. Yano, K. Arakawa, M. Nitta, O. Akasaka, S. Ryu, H. Himeno, T. Hatada, H. Imai, S. Nachi, H. Ushikoshi, S. Ogura, M. Mizobuchi, T. Kobayashi, K. Shibata, S. Nakamura, H. Kamura, A. Kataoka, Y. Honma, Y. Nishi, K. Niwa, T. Watanabe, T. Inohara, T. Takabayashi, S. Ishimatsu, J. Kotani, A. Hashimoto, S. Marukawa, K. Shiga, S. Asai, T. Hathaway, K. Kikuchi, M. Tokura, S. Nishino

研究成果: Article

42 引用 (Scopus)

抄録

Aim: To investigate the association between regional brain oxygen saturation (rSO2) at hospital arrival and neurological outcomes at 90 days in patients with out-of-hospital cardiac arrest (OHCA). Methods: The Japan-Prediction of neurological Outcomes in patients post cardiac arrest (J-POP) registry is a prospective, multicenter, cohort study to test whether rSO2 predicts neurological outcomes after OHCA. We measured rSO2 in OHCA patients immediately after hospital arrival using a near-infrared spectrometer placed on the forehead with non-blinded fashion. The primary endpoint was "neurological outcomes" at 90 days after OHCA. Results: EMS providers are not permitted to terminate CPR in the field in Japan, and so most patients with OHCA who are treated by EMS personnel are transported to emergency hospitals. Among 1017 OHCA patients, 672 patients including 52 comatose patients with pulses detectable (8%) and 620 cardiac arrest patients (92%) at hospital arrival were enrolled prospectively and consecutively. Twenty-nine patients with good neurological outcome had a significantly higher value of rSO2 at hospital arrival than 643 patients with poor neurological outcome (mean [±SD] 55.6±20.8% vs. 19.7±11.0%, p<0.001). Receiver operating curve analysis indicated an optimal rSO2 cutoff point of >42% for predicting good neurological outcome, with sensitivity 0.79 (95% confidence interval [CI], 0.60-0.92), specificity 0.95 (95% CI, 0.93-0.96), positive predictive value, 0.41 (95% CI, 0.28-0.55), negative predictive value, 0.99 (95% CI, 0.98-1.00), and area under the curve 0.90 (95% CI, 0.88-0.92). Conclusion: The rSO2 at hospital arrival can predict good neurological outcome at 90 days after OHCA.

元の言語English
ページ(範囲)778-784
ページ数7
ジャーナルResuscitation
85
発行部数6
DOI
出版物ステータスPublished - 2014

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Out-of-Hospital Cardiac Arrest
Multicenter Studies
Observational Studies
Oxygen
Confidence Intervals
Heart Arrest
Japan
Forehead
Cardiopulmonary Resuscitation
Coma
Area Under Curve
Registries
Emergencies
Cohort Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine
  • Medicine(all)

これを引用

Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest : A prospective multicenter observational study. / Ito, Noritoshi; Nishiyama, Kei; Callaway, Clifton W.; Orita, Tomohiko; Hayashida, Kei; Arimoto, Hideki; Abe, Mitsuru; Endo, Tomoyuki; Murai, Akira; Ishikura, Ken; Yamada, Noriaki; Mizobuchi, Masahiro; Anan, Hideki; Okuchi, Kazuo; Yasuda, Hideto; Mochizuki, Toshiaki; Tsujimura, Yuka; Nakayama, Takeo; Hatanaka, Tetsuo; Nagao, Ken; Suzuki, T.; Sato, N.; Kimura, T.; Koike, K.; Morooka, T.; Rinka, H.; Ikehara, T.; Suzuki, M.; Shirishita-Takeshita, A.; Hori, S.; Unoki, T.; Beppu, S.; Kaneko, I.; Toyoda, Y.; Kitano, M.; Machida, M.; Ishikura, H.; Oomura, T.; Kudo, D.; Kushimoto, S.; Watanabe, T.; Fujioka, M.; Seki, T.; Otsuka, M.; Yano, H.; Arakawa, K.; Nitta, M.; Akasaka, O.; Ryu, S.; Himeno, H.; Hatada, T.; Imai, H.; Nachi, S.; Ushikoshi, H.; Ogura, S.; Mizobuchi, M.; Kobayashi, T.; Shibata, K.; Nakamura, S.; Kamura, H.; Kataoka, A.; Honma, Y.; Nishi, Y.; Niwa, K.; Watanabe, T.; Inohara, T.; Takabayashi, T.; Ishimatsu, S.; Kotani, J.; Hashimoto, A.; Marukawa, S.; Shiga, K.; Asai, S.; Hathaway, T.; Kikuchi, K.; Tokura, M.; Nishino, S.

:: Resuscitation, 巻 85, 番号 6, 2014, p. 778-784.

研究成果: Article

Ito, N, Nishiyama, K, Callaway, CW, Orita, T, Hayashida, K, Arimoto, H, Abe, M, Endo, T, Murai, A, Ishikura, K, Yamada, N, Mizobuchi, M, Anan, H, Okuchi, K, Yasuda, H, Mochizuki, T, Tsujimura, Y, Nakayama, T, Hatanaka, T, Nagao, K, Suzuki, T, Sato, N, Kimura, T, Koike, K, Morooka, T, Rinka, H, Ikehara, T, Suzuki, M, Shirishita-Takeshita, A, Hori, S, Unoki, T, Beppu, S, Kaneko, I, Toyoda, Y, Kitano, M, Machida, M, Ishikura, H, Oomura, T, Kudo, D, Kushimoto, S, Watanabe, T, Fujioka, M, Seki, T, Otsuka, M, Yano, H, Arakawa, K, Nitta, M, Akasaka, O, Ryu, S, Himeno, H, Hatada, T, Imai, H, Nachi, S, Ushikoshi, H, Ogura, S, Mizobuchi, M, Kobayashi, T, Shibata, K, Nakamura, S, Kamura, H, Kataoka, A, Honma, Y, Nishi, Y, Niwa, K, Watanabe, T, Inohara, T, Takabayashi, T, Ishimatsu, S, Kotani, J, Hashimoto, A, Marukawa, S, Shiga, K, Asai, S, Hathaway, T, Kikuchi, K, Tokura, M & Nishino, S 2014, 'Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest: A prospective multicenter observational study', Resuscitation, 巻. 85, 番号 6, pp. 778-784. https://doi.org/10.1016/j.resuscitation.2014.02.012
Ito, Noritoshi ; Nishiyama, Kei ; Callaway, Clifton W. ; Orita, Tomohiko ; Hayashida, Kei ; Arimoto, Hideki ; Abe, Mitsuru ; Endo, Tomoyuki ; Murai, Akira ; Ishikura, Ken ; Yamada, Noriaki ; Mizobuchi, Masahiro ; Anan, Hideki ; Okuchi, Kazuo ; Yasuda, Hideto ; Mochizuki, Toshiaki ; Tsujimura, Yuka ; Nakayama, Takeo ; Hatanaka, Tetsuo ; Nagao, Ken ; Suzuki, T. ; Sato, N. ; Kimura, T. ; Koike, K. ; Morooka, T. ; Rinka, H. ; Ikehara, T. ; Suzuki, M. ; Shirishita-Takeshita, A. ; Hori, S. ; Unoki, T. ; Beppu, S. ; Kaneko, I. ; Toyoda, Y. ; Kitano, M. ; Machida, M. ; Ishikura, H. ; Oomura, T. ; Kudo, D. ; Kushimoto, S. ; Watanabe, T. ; Fujioka, M. ; Seki, T. ; Otsuka, M. ; Yano, H. ; Arakawa, K. ; Nitta, M. ; Akasaka, O. ; Ryu, S. ; Himeno, H. ; Hatada, T. ; Imai, H. ; Nachi, S. ; Ushikoshi, H. ; Ogura, S. ; Mizobuchi, M. ; Kobayashi, T. ; Shibata, K. ; Nakamura, S. ; Kamura, H. ; Kataoka, A. ; Honma, Y. ; Nishi, Y. ; Niwa, K. ; Watanabe, T. ; Inohara, T. ; Takabayashi, T. ; Ishimatsu, S. ; Kotani, J. ; Hashimoto, A. ; Marukawa, S. ; Shiga, K. ; Asai, S. ; Hathaway, T. ; Kikuchi, K. ; Tokura, M. ; Nishino, S. / Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest : A prospective multicenter observational study. :: Resuscitation. 2014 ; 巻 85, 番号 6. pp. 778-784.
@article{677b2df6723a49c78fc02068753990d3,
title = "Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest: A prospective multicenter observational study",
abstract = "Aim: To investigate the association between regional brain oxygen saturation (rSO2) at hospital arrival and neurological outcomes at 90 days in patients with out-of-hospital cardiac arrest (OHCA). Methods: The Japan-Prediction of neurological Outcomes in patients post cardiac arrest (J-POP) registry is a prospective, multicenter, cohort study to test whether rSO2 predicts neurological outcomes after OHCA. We measured rSO2 in OHCA patients immediately after hospital arrival using a near-infrared spectrometer placed on the forehead with non-blinded fashion. The primary endpoint was {"}neurological outcomes{"} at 90 days after OHCA. Results: EMS providers are not permitted to terminate CPR in the field in Japan, and so most patients with OHCA who are treated by EMS personnel are transported to emergency hospitals. Among 1017 OHCA patients, 672 patients including 52 comatose patients with pulses detectable (8{\%}) and 620 cardiac arrest patients (92{\%}) at hospital arrival were enrolled prospectively and consecutively. Twenty-nine patients with good neurological outcome had a significantly higher value of rSO2 at hospital arrival than 643 patients with poor neurological outcome (mean [±SD] 55.6±20.8{\%} vs. 19.7±11.0{\%}, p<0.001). Receiver operating curve analysis indicated an optimal rSO2 cutoff point of >42{\%} for predicting good neurological outcome, with sensitivity 0.79 (95{\%} confidence interval [CI], 0.60-0.92), specificity 0.95 (95{\%} CI, 0.93-0.96), positive predictive value, 0.41 (95{\%} CI, 0.28-0.55), negative predictive value, 0.99 (95{\%} CI, 0.98-1.00), and area under the curve 0.90 (95{\%} CI, 0.88-0.92). Conclusion: The rSO2 at hospital arrival can predict good neurological outcome at 90 days after OHCA.",
keywords = "Cardiac arrest, Cardiopulmonary resuscitation, Emergency department, Predictors, Regional brain oxygen saturation",
author = "Noritoshi Ito and Kei Nishiyama and Callaway, {Clifton W.} and Tomohiko Orita and Kei Hayashida and Hideki Arimoto and Mitsuru Abe and Tomoyuki Endo and Akira Murai and Ken Ishikura and Noriaki Yamada and Masahiro Mizobuchi and Hideki Anan and Kazuo Okuchi and Hideto Yasuda and Toshiaki Mochizuki and Yuka Tsujimura and Takeo Nakayama and Tetsuo Hatanaka and Ken Nagao and T. Suzuki and N. Sato and T. Kimura and K. Koike and T. Morooka and H. Rinka and T. Ikehara and M. Suzuki and A. Shirishita-Takeshita and S. Hori and T. Unoki and S. Beppu and I. Kaneko and Y. Toyoda and M. Kitano and M. Machida and H. Ishikura and T. Oomura and D. Kudo and S. Kushimoto and T. Watanabe and M. Fujioka and T. Seki and M. Otsuka and H. Yano and K. Arakawa and M. Nitta and O. Akasaka and S. Ryu and H. Himeno and T. Hatada and H. Imai and S. Nachi and H. Ushikoshi and S. Ogura and M. Mizobuchi and T. Kobayashi and K. Shibata and S. Nakamura and H. Kamura and A. Kataoka and Y. Honma and Y. Nishi and K. Niwa and T. Watanabe and T. Inohara and T. Takabayashi and S. Ishimatsu and J. Kotani and A. Hashimoto and S. Marukawa and K. Shiga and S. Asai and T. Hathaway and K. Kikuchi and M. Tokura and S. Nishino",
year = "2014",
doi = "10.1016/j.resuscitation.2014.02.012",
language = "English",
volume = "85",
pages = "778--784",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

TY - JOUR

T1 - Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest

T2 - A prospective multicenter observational study

AU - Ito, Noritoshi

AU - Nishiyama, Kei

AU - Callaway, Clifton W.

AU - Orita, Tomohiko

AU - Hayashida, Kei

AU - Arimoto, Hideki

AU - Abe, Mitsuru

AU - Endo, Tomoyuki

AU - Murai, Akira

AU - Ishikura, Ken

AU - Yamada, Noriaki

AU - Mizobuchi, Masahiro

AU - Anan, Hideki

AU - Okuchi, Kazuo

AU - Yasuda, Hideto

AU - Mochizuki, Toshiaki

AU - Tsujimura, Yuka

AU - Nakayama, Takeo

AU - Hatanaka, Tetsuo

AU - Nagao, Ken

AU - Suzuki, T.

AU - Sato, N.

AU - Kimura, T.

AU - Koike, K.

AU - Morooka, T.

AU - Rinka, H.

AU - Ikehara, T.

AU - Suzuki, M.

AU - Shirishita-Takeshita, A.

AU - Hori, S.

AU - Unoki, T.

AU - Beppu, S.

AU - Kaneko, I.

AU - Toyoda, Y.

AU - Kitano, M.

AU - Machida, M.

AU - Ishikura, H.

AU - Oomura, T.

AU - Kudo, D.

AU - Kushimoto, S.

AU - Watanabe, T.

AU - Fujioka, M.

AU - Seki, T.

AU - Otsuka, M.

AU - Yano, H.

AU - Arakawa, K.

AU - Nitta, M.

AU - Akasaka, O.

AU - Ryu, S.

AU - Himeno, H.

AU - Hatada, T.

AU - Imai, H.

AU - Nachi, S.

AU - Ushikoshi, H.

AU - Ogura, S.

AU - Mizobuchi, M.

AU - Kobayashi, T.

AU - Shibata, K.

AU - Nakamura, S.

AU - Kamura, H.

AU - Kataoka, A.

AU - Honma, Y.

AU - Nishi, Y.

AU - Niwa, K.

AU - Watanabe, T.

AU - Inohara, T.

AU - Takabayashi, T.

AU - Ishimatsu, S.

AU - Kotani, J.

AU - Hashimoto, A.

AU - Marukawa, S.

AU - Shiga, K.

AU - Asai, S.

AU - Hathaway, T.

AU - Kikuchi, K.

AU - Tokura, M.

AU - Nishino, S.

PY - 2014

Y1 - 2014

N2 - Aim: To investigate the association between regional brain oxygen saturation (rSO2) at hospital arrival and neurological outcomes at 90 days in patients with out-of-hospital cardiac arrest (OHCA). Methods: The Japan-Prediction of neurological Outcomes in patients post cardiac arrest (J-POP) registry is a prospective, multicenter, cohort study to test whether rSO2 predicts neurological outcomes after OHCA. We measured rSO2 in OHCA patients immediately after hospital arrival using a near-infrared spectrometer placed on the forehead with non-blinded fashion. The primary endpoint was "neurological outcomes" at 90 days after OHCA. Results: EMS providers are not permitted to terminate CPR in the field in Japan, and so most patients with OHCA who are treated by EMS personnel are transported to emergency hospitals. Among 1017 OHCA patients, 672 patients including 52 comatose patients with pulses detectable (8%) and 620 cardiac arrest patients (92%) at hospital arrival were enrolled prospectively and consecutively. Twenty-nine patients with good neurological outcome had a significantly higher value of rSO2 at hospital arrival than 643 patients with poor neurological outcome (mean [±SD] 55.6±20.8% vs. 19.7±11.0%, p<0.001). Receiver operating curve analysis indicated an optimal rSO2 cutoff point of >42% for predicting good neurological outcome, with sensitivity 0.79 (95% confidence interval [CI], 0.60-0.92), specificity 0.95 (95% CI, 0.93-0.96), positive predictive value, 0.41 (95% CI, 0.28-0.55), negative predictive value, 0.99 (95% CI, 0.98-1.00), and area under the curve 0.90 (95% CI, 0.88-0.92). Conclusion: The rSO2 at hospital arrival can predict good neurological outcome at 90 days after OHCA.

AB - Aim: To investigate the association between regional brain oxygen saturation (rSO2) at hospital arrival and neurological outcomes at 90 days in patients with out-of-hospital cardiac arrest (OHCA). Methods: The Japan-Prediction of neurological Outcomes in patients post cardiac arrest (J-POP) registry is a prospective, multicenter, cohort study to test whether rSO2 predicts neurological outcomes after OHCA. We measured rSO2 in OHCA patients immediately after hospital arrival using a near-infrared spectrometer placed on the forehead with non-blinded fashion. The primary endpoint was "neurological outcomes" at 90 days after OHCA. Results: EMS providers are not permitted to terminate CPR in the field in Japan, and so most patients with OHCA who are treated by EMS personnel are transported to emergency hospitals. Among 1017 OHCA patients, 672 patients including 52 comatose patients with pulses detectable (8%) and 620 cardiac arrest patients (92%) at hospital arrival were enrolled prospectively and consecutively. Twenty-nine patients with good neurological outcome had a significantly higher value of rSO2 at hospital arrival than 643 patients with poor neurological outcome (mean [±SD] 55.6±20.8% vs. 19.7±11.0%, p<0.001). Receiver operating curve analysis indicated an optimal rSO2 cutoff point of >42% for predicting good neurological outcome, with sensitivity 0.79 (95% confidence interval [CI], 0.60-0.92), specificity 0.95 (95% CI, 0.93-0.96), positive predictive value, 0.41 (95% CI, 0.28-0.55), negative predictive value, 0.99 (95% CI, 0.98-1.00), and area under the curve 0.90 (95% CI, 0.88-0.92). Conclusion: The rSO2 at hospital arrival can predict good neurological outcome at 90 days after OHCA.

KW - Cardiac arrest

KW - Cardiopulmonary resuscitation

KW - Emergency department

KW - Predictors

KW - Regional brain oxygen saturation

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U2 - 10.1016/j.resuscitation.2014.02.012

DO - 10.1016/j.resuscitation.2014.02.012

M3 - Article

C2 - 24606889

AN - SCOPUS:84901289426

VL - 85

SP - 778

EP - 784

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

IS - 6

ER -