Nonnatural glycosyl anthraquinones as DNA binding and photocleaving agents

研究成果: Chapter

3 被引用数 (Scopus)

抄録

Several artificial anthraquinone-carbohydrate hybrids were designed and synthesized. A selectednumber of hybrids did bind to DNA via intercalation in a sequence-selective manner, leading to inhibitionof DNA cleavage by DNase I, whereas other hybrids cleaved DNA with base selectivity upon photoirradiation.This hybrid system was found to be very important for both DNA binding and photocleaving.

本文言語English
ホスト出版物のタイトルAnthracycline Chemistry and Biology I
ホスト出版物のサブタイトルBiological Occurence and Biosynthesis, Synthesis and Chemistry
編集者Karsten Krohn
ページ285-298
ページ数14
DOI
出版ステータスPublished - 2008 12 1

出版物シリーズ

名前Topics in Current Chemistry
282
ISSN(印刷版)0340-1022

ASJC Scopus subject areas

  • Chemistry(all)

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