Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from Actinomadura sp.

Yasuhiro Igarashi, Noriaki Matsuoka, Yasuko In, Tetsushi Kataura, Etsu Tashiro, Ikuo Saiki, Yuri Sudoh, Kannika Duangmal, Arinthip Thamchaipenet

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Nonthmicin (1), a new polyether polyketide bearing a chlorinated tetronic acid, was isolated from the culture extract of a soil-derived Actinomadura strain. The structure of 1 was elucidated by interpretation of NMR and MS spectroscopic data, and the absolute configuration of 1 was proposed on the basis of the crystal structure of its dechloro congener ecteinamycin (2) also isolated from the same strain. Tetronic acids modified by halogenation have never been reported from natural products. Compounds 1 and 2 were found to have neuroprotective activity and antimetastatic properties at submicromolar concentrations in addition to antibacterial activity.

本文言語English
ページ(範囲)1406-1409
ページ数4
ジャーナルOrganic Letters
19
6
DOI
出版ステータスPublished - 2017 3 17

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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