Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

Yoshimasa Matsuda, Yoshio Wakamatsu, Jun Kohyama, Hideyuki Okano, Kimiko Fukuda, Sadao Yasugi

研究成果: Article査読

33 被引用数 (Scopus)

抄録

During development of the chicken proventriculus (glandular stomach), gut endoderm differentiates into glandular and luminal epithelium. We found that Delta1-expressing cells, undifferentiated cells and Notch-activated cells colocalize within the endodermal epithelium during early gland formation. Inhibition of Notch signaling using Numb or dominant-negative form of Su(H) resulted in a luminal differentiation, while forced activation of Notch signaling promoted the specification of immature glandular cells, but prevented the subsequent differentiation and the imagination of the glands. These results suggest that Delta1-mediated Notch signaling among endodermal cells functions as a binary switch for determination of glandular and luminal fates, and regulates patterned differentiation of glands in the chicken proventriculus.

本文言語English
ページ(範囲)2783-2793
ページ数11
ジャーナルDevelopment
132
12
DOI
出版ステータスPublished - 2005 6月

ASJC Scopus subject areas

  • 分子生物学
  • 発生生物学

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