Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis

Shigeaki Suzuki, Takashi Satoh, Hidekata Yasuoka, Yasuhito Hamaguchi, Kortaro Tanaka, Yutaka Kawakami, Norihiro Suzuki, Masataka Kuwana

研究成果: Article査読

63 被引用数 (Scopus)

抄録

Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.

本文言語English
ページ(範囲)141-149
ページ数9
ジャーナルJournal of Neuroimmunology
170
1-2
DOI
出版ステータスPublished - 2005 12 30

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

フィンガープリント

「Novel autoantibodies to a voltage-gated potassium channel K<sub>V</sub>1.4 in a severe form of myasthenia gravis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル