Novel heparan sulfate mimetic compounds as antitumor agents

Keisuke Ishida, Michal K. Wierzba, Takayuki Teruya, Siro Simizu, Hiroyuki Osada

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Heparan sulfate glycosaminoglycans (HSGAGs) are involved in tumor cell growth, adhesion, invasion, and migration, due to their interactions with various proteins. In this study, novel HSGAG-mimetic compounds (KI compounds) were designed and synthesized. As a result of cell-based assays, KI-105 was found to exert potent inhibitory activities against migration and invasion of human fibrosarcoma HT1080 cells. The present results indicate that a novel invasion/migration inhibitor, KI-105, can increase the adherence of HT1080 cells. It was conceivable that this cellular effect was caused by an increase in the amount of cell-surface HSGAGs and focal adhesions. Although further investigations are needed to decipher the molecular mechanism of KI-105, it is suggested that heparanase and Cdc42 are involved in its biological effects.

本文言語English
ページ(範囲)367-377
ページ数11
ジャーナルChemistry and Biology
11
3
DOI
出版ステータスPublished - 2004 3
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬理学
  • 創薬
  • 臨床生化学

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