Novel Isoforms of Mouse Myelin Basic Protein Predominantly Expressed in Embryonic Stage

Kazunori Nakajima, Kazuhiro Ikenaka, Tetsushi Kagawa, Jun Aruga, Junji Nakao, Kensuke Nakahira, Chiyo Shiota, Seung U. Kim, Katsuhiko Mikoshiba

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Abstract: Myelin basic protein (MBP), a major protein of myelin, is thought to play an important role in myelination, which occurs postnatally in mouse. Here we report that the MBP gene is expressed from the 12th embryonic day in mouse brain and that most of the predominant embryonic isoforms are not those reported previously. These isoforms have a deletion of a sequence encoded by exon 5 from the well‐known isoforms. These isoforms show a unique developmental profile, i.e., they peak in the embryonic stage and decrease thereafter. In jimpy, a dysmyelinating mutant, the level of these isoforms remains high even in the older ages. These results suggest that MBPs have heretofore unknown functions unrelated to myelination before myelinogenesis begins. The possible presence of 18 isoforms of MBP mRNA, which are classified into at least three groups with different developmental profiles, is also reported here.

本文言語English
ページ(範囲)1554-1563
ページ数10
ジャーナルJournal of Neurochemistry
60
4
DOI
出版ステータスPublished - 1993 4月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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