Novel metabolic pathway of estrone and 17β-estradiol catalyzed by cytochrome P-450

研究成果: Article

42 被引用数 (Scopus)

抄録

We have already reported that the quinol formation from some para- alkylphenols, which is a novel metabolic pathway catalyzed by cytochrome P- 450, occurs in a rat liver microsomal system (Ohe et al., 1997). In the present study, we investigated whether estrone and 17β-estadiol, each of which contains a p-alkylphenol moiety, are also oxidized into the corresponding quinols by cytochrome P-450. Six recombinant human cytochrome P-450 enzymes, CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2E1, and CYP3A4, were tested. The results show that estrone and 17β-estadiol were converted into the corresponding quinols by CYP1A1, CYP2B6, and CYP2E1.

本文言語English
ページ(範囲)110-112
ページ数3
ジャーナルDrug Metabolism and Disposition
28
2
出版ステータスPublished - 2000 2 9

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

フィンガープリント 「Novel metabolic pathway of estrone and 17β-estradiol catalyzed by cytochrome P-450」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル