Novel metabolic pathways of p-n-nonylphenol catalyzed by cytochrome P450 and estrogen receptor binding activity of new metabolites

Medicine & Life Sciences

• nonylphenol 100%
• Metabolic Networks and Pathways 63%
• Cytochrome P-450 Enzyme System 61%
• Estrogen Receptors 58%
• hydroxide ion 35%
• hydroquinone 33%
• Carbon Monoxide 24%
• Cytochrome P-450 CYP2B6 22%
• Cytochrome P-450 CYP1A1 19%
• Liver Microsomes 18%
• Isoenzymes 15%
• Metabolic Inactivation 13%
• Phenols 10%
• Endocrine Disruptors 10%
• Biotransformation 9%
• Hydroxylation 9%
• Surface-Active Agents 8%
• Reporter Genes 7%

Chemical Compounds

• Receptor Binding Activity 94%
• Nonylphenol 83%
• Estrogen 67%
• Cytochrome P450 67%
• Metabolic 51%
• Metabolite 44%
• Hydroquinone 24%
• Nonan-1-Ol 14%
• P450 Inhibitor 12%
• Endocrine Disruptor 9%
• Mixture 6%
• Pharmacological Metabolism 6%
• Phenol 5%
• Surfactant 5%
• Amount 3%