Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1

Tomoyuki Ohe; Tadahiko Mashino; Masaaki Hirobe

doi:10.1016/0040-4039(95)01611-K

Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species¹

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

研究成果: Article › 査読

30 被引用数 (Scopus)

抄録

The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [¹⁸O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.

本文言語	English
ページ（範囲）	7681-7684
ページ数	4
ジャーナル	Tetrahedron Letters
巻	36
号	42
DOI	https://doi.org/10.1016/0040-4039(95)01611-K
出版ステータス	Published - 1995 10 16
外部発表	はい

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

文献へのアクセス

10.1016/0040-4039(95)01611-K

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フィンガープリント「Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species<sup>1</sup>」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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abstract = "The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [18O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.",

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