Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1

Tomoyuki Ohe; Tadahiko Mashino; Masaaki Hirobe

doi:10.1016/0040-4039(95)01611-K

Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species¹

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

研究成果: Article › 査読

31 被引用数 (Scopus)

抄録

The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [¹⁸O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.

本文言語	English
ページ（範囲）	7681-7684
ページ数	4
ジャーナル	Tetrahedron Letters
巻	36
号	42
DOI	https://doi.org/10.1016/0040-4039(95)01611-K
出版ステータス	Published - 1995 10月 16
外部発表	はい

ASJC Scopus subject areas

生化学
創薬
有機化学

文献へのアクセス

10.1016/0040-4039(95)01611-K

他のファイルとリンク

フィンガープリント

「Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species¹」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{7b97e490b3e6436a99db7f82d602705b,

title = "Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1",

abstract = "The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [18O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.",

author = "Tomoyuki Ohe and Tadahiko Mashino and Masaaki Hirobe",

year = "1995",

month = oct,

day = "16",

doi = "10.1016/0040-4039(95)01611-K",

language = "English",

volume = "36",

pages = "7681--7684",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "42",

}

TY - JOUR

T1 - Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model

T2 - Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1

AU - Ohe, Tomoyuki

AU - Mashino, Tadahiko

AU - Hirobe, Masaaki

PY - 1995/10/16

Y1 - 1995/10/16

N2 - The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [18O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.

AB - The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [18O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.

UR - http://www.scopus.com/inward/record.url?scp=0028863957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028863957&partnerID=8YFLogxK

U2 - 10.1016/0040-4039(95)01611-K

DO - 10.1016/0040-4039(95)01611-K

M3 - Article

AN - SCOPUS:0028863957

VL - 36

SP - 7681

EP - 7684

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 42

ER -