TY - JOUR
T1 - Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds
AU - Kikuchi, Haruhisa
AU - Ishiko, Shinya
AU - Nakamura, Koji
AU - Kubohara, Yuzuru
AU - Oshima, Yoshiteru
N1 - Funding Information:
This work was supported in part by Chugai Pharmaceutical Co., Ltd. and a Grant-in-Aid for Scientific Research (No. 21590090 ) from the Ministry of Education, Science, Sports and Culture of Japan (Y.K.) . The authors thank Ms. K. Nakata for her technical assistance.
PY - 2010/8/7
Y1 - 2010/8/7
N2 - We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells.
AB - We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells.
KW - Cellular slime molds
KW - Geranylated aromatic compounds
KW - Glucose consumption
KW - Polysphondylium tenuissimum
KW - Prenylated aromatic compounds
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U2 - 10.1016/j.tet.2010.06.029
DO - 10.1016/j.tet.2010.06.029
M3 - Article
AN - SCOPUS:77955412521
SN - 0040-4020
VL - 66
SP - 6000
EP - 6007
JO - Tetrahedron
JF - Tetrahedron
IS - 32
ER -