Novel ring-opening polymerization of lactide by lipase

Shuichi Matsumura, Kimihiro Mabuchi, Kazunobu Toshima

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Six-membered D,L-, L,L- and D,D-lactides were polymerized by lipase over a temperature range of 80 to 130°C to yield the polylactide with a molecular weight (MW) of greater than 270000. Among the lipases tested, lipase PS gave the greatest molecular weight of polylactide. The polymerization of D,L-lactide by lipase was better than that of L,L- and D,D-lactides. The polymerization of lactide by lipase showed the characteristic features, such as induction period for the initiation of polymerization, formation of oligomer and subsequent formation of high molecular weight polylactide, which may imply the characteristic polymerization by lipase. Immobilization of lipase on celite significantly enhanced the polymerization of lactide particularly with respect to the low concentration of the enzyme and the MW of the resultant polymer. It was found that there is no clear relationship between enzymatic polymerizability and enzymatic degradability with respect to the enzyme origin and the stereochemistry of lactide.

本文言語English
ページ(範囲)285-304
ページ数20
ジャーナルMacromolecular Symposia
130
DOI
出版ステータスPublished - 1998 4月

ASJC Scopus subject areas

  • 凝縮系物理学
  • 有機化学
  • ポリマーおよびプラスチック
  • 材料化学

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