Novel screening method for agents that overcome classical multidrug resistance in a human cell line

A. Yoshimura, N. Shudo, S. I. Ikeda, M. Ichikawa, T. Sumizawa, S. I. Akiyama

研究成果: Article

31 引用 (Scopus)

抜粋

P-glycoprotein (P-gp) is involved in the transport of a wide variety of organic compounds including a fluorescent dye, rhodamine 6G (RG), as well as anti-cancer drugs. Agents that overcome classical multidrugresistance (MDR) increased the accumulation of RG in an MDR cell line, KB-C1. The effect of agents on RG-accumulation in KB-C1 cells was highly correlated with their effect on the reversion of vincristine-resistance in KB-C1 cells. RG was detected on a fluorescence microplate reader with a rhodamine channel. This assay may become a useful method for the screening of agents that overcome classical MBR, since it is quick and simple.

元の言語English
ページ(範囲)45-51
ページ数7
ジャーナルCancer Letters
50
発行部数1
DOI
出版物ステータスPublished - 1990 4 9
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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