Numerical simulation of oxygen transport in cerebral tissue

Toshihiro Kondo, Kazunori Oyama, Hidefumi Komatsu, Toshihiko Sugiura

研究成果: Conference contribution

抄録

The physiological mechanism of coupling between neuronal activity, metabolism and cerebral blood flow (CBF) is not clarified enough. In this study, the authors have examined activity-dependent changes in oxygen partial pressure (pO2) and CBF response in an arteriole by 2-dimensional numerical simulation with a mathematical model of O2 transport from the arteriole to its surrounding tissue including an adjusting function of CBF. In the steady state of O2 consumption, an area in the tissue where O2 is supplied from the arteriole becomes smaller as O2 consumption rate of the tissue increases, which is accompanied by increase of CBF. Therefore decrease of the O2- supplied area gradually becomes stagnant. Unsteady responses of the local pO2 and CBF were also examined. The response of pO2 in the upstream area of the arteriole is monophasic increment corresponding to CBF response, whereas the response in the middle area is biphasic response showing an initial decrease followed by a positive peak. In the downstream area, advective flow holds decrement of the pO2. Delay in CBF response to neuronal activity has also been found.

本文言語English
ホスト出版物のタイトルOxygen Transport to Tissue XXX
編集者Per Liss, Peter Hansell, Duane Bruley, David Harrison
ページ147-153
ページ数7
DOI
出版ステータスPublished - 2009 12 1

出版物シリーズ

名前Advances in Experimental Medicine and Biology
645
ISSN(印刷版)0065-2598

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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