Obesity, insulin resistance and the implication of thiazolidinediones

Yuko Oguma, K. Kataoka

研究成果: Article

抄録

The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity.

元の言語English
ページ(範囲)411-415
ページ数5
ジャーナルNippon rinsho. Japanese journal of clinical medicine
58
発行部数2
出版物ステータスPublished - 2000

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Thiazolidinediones
Insulin Resistance
Obesity
Adipose Tissue
Intra-Abdominal Fat
Facilitative Glucose Transport Proteins
Lipoma
Insulin Receptor
Nonesterified Fatty Acids
Protein-Tyrosine Kinases
Muscle Cells
Weight Gain
Tumor Necrosis Factor-alpha
Cell Count
Eating
Muscles

これを引用

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