OCT assessment of tear meniscus after punctal occlusion in dry eye disease

Osama M A Ibrahim, Murat Dogru, Takashi Kojima, Yukihiro Matsumoto, Tais Hitomi Wakamatsu, Kazuo Tsubota, Hiroshi Fujishima

研究成果: Article

17 引用 (Scopus)

抄録

PURPOSE.: To evaluate the tear meniscus changes after punctal occlusion in dry eye patients using Visante optical coherence tomography (OCT) in a prospective controlled study. METHODS.: Thirty eyes of 15 symptomatic dry eye patients not responding to non-preserved artificial tears received additional upper and lower punctal occlusion with silicone plugs, and 30 eyes of 15 age-and sex-matched dry eye control patients received only non-preserved artificial tears treatment for 1 month. All subjects underwent tear meniscus height (TMH) measurements with Visante OCT. All study participants also underwent slitmicroscopy graticule scale TMH measurement, strip meniscometry testing, tear film break-up time measurement, ocular surface vital staining with fluorescein and Rose Bengal dyes, and the Schirmer-1 test. Both groups, dry eye and control group patients, were examined before and after 1-month treatment. Wilcoxon-matched pair test was performed. The study was conducted in compliance with the Tenets of the Declaration of Helsinki. RESULTS.: TMH measurements by OCT and slitlamp graticule scale significantly improved after punctal occlusion (p < 0.001) and remain unchanged in the dry eye control patients. Similarly, strip meniscometry scores, mean tear stability values, Rose Bengal, and fluorescein staining scores showed significant improvement after punctal occlusion (p < 0.05). Schirmer-1 test values tended to be higher after 1 month of treatment in both groups without any statistical significance (p > 0.05). CONCLUSIONS.: OCT TMH measurement appears to be effective in monitoring tear meniscus changes after punctal occlusion. OCT can be a valuable non-invasive and quick clinical tool for evaluation of treatment responses in dry eye patients.

元の言語English
ジャーナルOptometry and Vision Science
89
発行部数5
DOI
出版物ステータスPublished - 2012 5

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Eye Diseases
Optical Coherence Tomography
Tears
Helsinki Declaration
Rose Bengal
Meniscus
Silicones
Fluorescein
Coloring Agents
Therapeutics
Prospective Studies
Staining and Labeling
Control Groups

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Medicine(all)

これを引用

Ibrahim, O. M. A., Dogru, M., Kojima, T., Matsumoto, Y., Wakamatsu, T. H., Tsubota, K., & Fujishima, H. (2012). OCT assessment of tear meniscus after punctal occlusion in dry eye disease. Optometry and Vision Science, 89(5). https://doi.org/10.1097/OPX.0b013e31824eeb07

OCT assessment of tear meniscus after punctal occlusion in dry eye disease. / Ibrahim, Osama M A; Dogru, Murat; Kojima, Takashi; Matsumoto, Yukihiro; Wakamatsu, Tais Hitomi; Tsubota, Kazuo; Fujishima, Hiroshi.

:: Optometry and Vision Science, 巻 89, 番号 5, 05.2012.

研究成果: Article

Ibrahim, OMA, Dogru, M, Kojima, T, Matsumoto, Y, Wakamatsu, TH, Tsubota, K & Fujishima, H 2012, 'OCT assessment of tear meniscus after punctal occlusion in dry eye disease', Optometry and Vision Science, 巻. 89, 番号 5. https://doi.org/10.1097/OPX.0b013e31824eeb07
Ibrahim, Osama M A ; Dogru, Murat ; Kojima, Takashi ; Matsumoto, Yukihiro ; Wakamatsu, Tais Hitomi ; Tsubota, Kazuo ; Fujishima, Hiroshi. / OCT assessment of tear meniscus after punctal occlusion in dry eye disease. :: Optometry and Vision Science. 2012 ; 巻 89, 番号 5.
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AU - Ibrahim, Osama M A

AU - Dogru, Murat

AU - Kojima, Takashi

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AU - Wakamatsu, Tais Hitomi

AU - Tsubota, Kazuo

AU - Fujishima, Hiroshi

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N2 - PURPOSE.: To evaluate the tear meniscus changes after punctal occlusion in dry eye patients using Visante optical coherence tomography (OCT) in a prospective controlled study. METHODS.: Thirty eyes of 15 symptomatic dry eye patients not responding to non-preserved artificial tears received additional upper and lower punctal occlusion with silicone plugs, and 30 eyes of 15 age-and sex-matched dry eye control patients received only non-preserved artificial tears treatment for 1 month. All subjects underwent tear meniscus height (TMH) measurements with Visante OCT. All study participants also underwent slitmicroscopy graticule scale TMH measurement, strip meniscometry testing, tear film break-up time measurement, ocular surface vital staining with fluorescein and Rose Bengal dyes, and the Schirmer-1 test. Both groups, dry eye and control group patients, were examined before and after 1-month treatment. Wilcoxon-matched pair test was performed. The study was conducted in compliance with the Tenets of the Declaration of Helsinki. RESULTS.: TMH measurements by OCT and slitlamp graticule scale significantly improved after punctal occlusion (p < 0.001) and remain unchanged in the dry eye control patients. Similarly, strip meniscometry scores, mean tear stability values, Rose Bengal, and fluorescein staining scores showed significant improvement after punctal occlusion (p < 0.05). Schirmer-1 test values tended to be higher after 1 month of treatment in both groups without any statistical significance (p > 0.05). CONCLUSIONS.: OCT TMH measurement appears to be effective in monitoring tear meniscus changes after punctal occlusion. OCT can be a valuable non-invasive and quick clinical tool for evaluation of treatment responses in dry eye patients.

AB - PURPOSE.: To evaluate the tear meniscus changes after punctal occlusion in dry eye patients using Visante optical coherence tomography (OCT) in a prospective controlled study. METHODS.: Thirty eyes of 15 symptomatic dry eye patients not responding to non-preserved artificial tears received additional upper and lower punctal occlusion with silicone plugs, and 30 eyes of 15 age-and sex-matched dry eye control patients received only non-preserved artificial tears treatment for 1 month. All subjects underwent tear meniscus height (TMH) measurements with Visante OCT. All study participants also underwent slitmicroscopy graticule scale TMH measurement, strip meniscometry testing, tear film break-up time measurement, ocular surface vital staining with fluorescein and Rose Bengal dyes, and the Schirmer-1 test. Both groups, dry eye and control group patients, were examined before and after 1-month treatment. Wilcoxon-matched pair test was performed. The study was conducted in compliance with the Tenets of the Declaration of Helsinki. RESULTS.: TMH measurements by OCT and slitlamp graticule scale significantly improved after punctal occlusion (p < 0.001) and remain unchanged in the dry eye control patients. Similarly, strip meniscometry scores, mean tear stability values, Rose Bengal, and fluorescein staining scores showed significant improvement after punctal occlusion (p < 0.05). Schirmer-1 test values tended to be higher after 1 month of treatment in both groups without any statistical significance (p > 0.05). CONCLUSIONS.: OCT TMH measurement appears to be effective in monitoring tear meniscus changes after punctal occlusion. OCT can be a valuable non-invasive and quick clinical tool for evaluation of treatment responses in dry eye patients.

KW - dry eye

KW - OCT

KW - punctal plug

KW - tear meniscus

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