Purpose: To discuss the importance of ocular surface management in corneal transplantation, especially in limbal transplantation. Methods: Since the corneal epithelium is not completely recovered after corneal transplantation, meticulous attention should be paid to the ocular surface to prevent infection and rejection, which are the major causes of corneal transplantation failure. Preoperative evaluations of the ocular surface should be carried out, followed by appropriate surgical procedures, depending on the condition of each patient. Vigorous immunosuppressive measures should be taken after surgery. Results: In both case reports presented in this study, each patient underwent successful surgery and his condition was controlled by medication suited to his needs. Conclusions: For those patients with stem cell deficiency, limbal transplantation, possibly with the use of autologous serum drops, should be considered to reconstruct and maintain the ocular surface. Ocular surface management is necessary for the success of corneal transplantation, especially for limbal transplantation.
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