Odoamide, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Okeania sp.

Kosuke Sueyoshi, Masato Kaneda, Shinpei Sumimoto, Shinya Oishi, Nobutaka Fujii, Kiyotake Suenaga, Toshiaki Teruya

研究成果: Article査読

25 被引用数 (Scopus)

抄録

The bioassay-guided fractionation of the Okinawan marine cyanobacterium Okeania sp. led to the isolation of the 26-membered cyclodepsipeptide odoamide (1). The gross structure of 1 was determined by 1D and 2D NMR analyses, whereas its absolute stereochemistry was determined using a variety of different methods, including synthesis and chemical degradation followed by chiral HPLC analysis. Notably, odoamide (1) showed potent cytotoxicity against HeLa S3 human cervical cancer cells with an IC50value of 26.3 nM.

本文言語English
ページ(範囲)5472-5478
ページ数7
ジャーナルTetrahedron
72
35
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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