Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Yasue Horiuchi, Shin ichi Kano, Koko Ishizuka, Nicola G. Cascella, Seiji Ishii, C. Conover Talbot, Andrew E. Jaffe, Hideyuki Okano, Jonathan Pevsner, Carlo Colantuoni, Akira Sawa

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.

本文言語English
ページ(範囲)247-250
ページ数4
ジャーナルNeuroscience Research
77
4
DOI
出版ステータスPublished - 2013 12

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 「Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル