Olfactory neuroblastoma (ONB) is a rare nasal malignancy. Because of its rarity, established treatments are lacking. The present retrospective study investigated the efficacy of CADO-CVP against ONB in 31 patients initially treated in the Department of Head and Neck at the Cancer Institute Hospital between 1992 and 2012. We have previously administered CADO-CVP as induction chemotherapy, achieving a high response rate. Fiveyear overall and disease-free survival rates were 82% and 53%, respectively. Disease-free survival rates differed significantly between the groups with and without induction chemotherapy. Four patients showed recurrence at over 5 years after initial treatment. We therefore consider that long-term follow-up is important for patients with ONB.
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