Oligomycin induced the proteasomal degradation of cyclin D1 protein

Mai Kanai, Satoru Iba, Ryoko Okada, Etsu Tashiro, Masaya Imoto

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We searched for compounds that affect the cyclin D1/retinoblastoma protein pathway from the in-house natural product library using a recombinant adenovirus with the Cre/loxP-regulated cyclin D1 overexpression system, and we found that oligomycin inhibited cell growth more effectively in cyclin D1-overexpressing SW480 cells than in control SW480 cells. We also found that oligomycin reduced the expression levels of cyclin D1 protein and that this reduction is, at least in part, mediated by Thr-286 phosphorylation-dependent proteasomal degradation.

本文言語English
ページ(範囲)425-429
ページ数5
ジャーナルJournal of Antibiotics
62
8
DOI
出版ステータスPublished - 2009 8月

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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