Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Tomoaki Ishihara, Mio Yoshida, Makoto Arita

研究成果: Review article査読

44 被引用数 (Scopus)

抄録

Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.

本文言語English
ページ(範囲)559-567
ページ数9
ジャーナルInternational immunology
31
9
DOI
出版ステータスPublished - 2019 9 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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