TY - JOUR
T1 - Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach
AU - Kakei, Nobuyuki
AU - Ichinose, Masao
AU - Tsukada, Shinko
AU - Tatematsu, Masae
AU - Tezuka, Noriaki
AU - Yahagi, Naohisa
AU - Matsushima, Masashi
AU - Miki, Kazumasa
AU - Kurokawa, Kiyoshi
AU - Takahashi, Kenji
AU - Fukamachi, Hhiroshi
PY - 1993/9/15
Y1 - 1993/9/15
N2 - Omeprazole, a proton pump inhibitor, dose-dependently inhibited pepsinogen secretion as well as acid secretion in the rat glandular stomach. The reduction in the secretion was rapid and was followed by a decrease in the mRNA levels. The inhibitory effect of omeprazole on pepsinogen secretion and its effect on the mRNA level showed similar dose-response relationship, suggesting that pepsinogen secretion and the gene expression are regulated coordinately. Consistent with the reduction in the mRNA levels, protein synthesis was reduced. However, intracellular stores of pepsinogen increased in pepsinogen-producing cells, indicating that the inhibitory effect of omeprazole on pepsinogen secretion is greater than on its synthesis. Reducing the secretion, synthesis and gene expression of pepsinogen, omeprazole has a potent effect on pepsinogen-producing cells in vivo, as well as on parietal cells, in the rat glandular stomach.
AB - Omeprazole, a proton pump inhibitor, dose-dependently inhibited pepsinogen secretion as well as acid secretion in the rat glandular stomach. The reduction in the secretion was rapid and was followed by a decrease in the mRNA levels. The inhibitory effect of omeprazole on pepsinogen secretion and its effect on the mRNA level showed similar dose-response relationship, suggesting that pepsinogen secretion and the gene expression are regulated coordinately. Consistent with the reduction in the mRNA levels, protein synthesis was reduced. However, intracellular stores of pepsinogen increased in pepsinogen-producing cells, indicating that the inhibitory effect of omeprazole on pepsinogen secretion is greater than on its synthesis. Reducing the secretion, synthesis and gene expression of pepsinogen, omeprazole has a potent effect on pepsinogen-producing cells in vivo, as well as on parietal cells, in the rat glandular stomach.
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U2 - 10.1006/bbrc.1993.2143
DO - 10.1006/bbrc.1993.2143
M3 - Article
C2 - 7690564
AN - SCOPUS:0027305788
SN - 0006-291X
VL - 195
SP - 997
EP - 1004
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -