On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source

Seishi Nakatsuka, Hideki Yashiro, Masanori Inoue, Sachio Kuribayashi, Masafumi Kawamura, Yotaro Izumi, Norimasa Tsukada, Yoshikane Yamauchi, Kohei Hashimoto, Kansei Iwata, Taisuke Nagasawa, Yi Shan Lin

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Regarding cryoablation for the malignant lung tumors, multiple trials of the freeze-thaw process have been made, and we considered it necessary to view and analyze the freeze-thaw process as a freeze-thaw sequence. We caused the sequence in a porcine lung. in vivo by using an acicular, cylindrical stainless-steel probe as the heat source for the freeze-thaw sequence and cooling to -150 °C with super high-pressure argon gas by causing the Joule-Thomson effect phenomenon at the tip of the probe. In this experiment, we examined the sequence by measuring the temperature and using the isothermal curve and the freezing function. As a result, it was demonstrated that the freezing characteristics considerably differed in the first sequence and the second sequence from those of non-aerated organs such as liver and kidney. In our experiments on porcine lung, thermal properties were considered to change as the bleeding caused by the first thawing infiltrated in the lung parenchyma, and it was confirmed that the frozen area in the second cycle was dramatically enlarged as compared with the first cycle (when a similar sequence is continuously repeated, we say it as cycle). This paper provides these details.

本文言語English
ページ(範囲)317-326
ページ数10
ジャーナルCryobiology
61
3
DOI
出版ステータスPublished - 2010 12月

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)

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